Oxytocic administration errors are a significant source of professional liability. Non compliance with oxytocic drug guidelines is a serious, widespread problem among nurses. Objective: The aim of this research was to identify nurses’ level of compliance with oxytocic administration guidelines during labor. Setting: The study was conducted in four hospitals in Alexandria, El-Shatby Maternity University Hospital, EL-Gomhoria Hospital, Gamal Abdel Nasser Hospital and Dar El-Welada Hospital. Subjects: The study sample composed of 120 nurses working in the previously mentioned settings and providing direct care for laboring women. Tools: Three tools were validated and used: Tool I: Socio-demographic data questionnaire sheet, Tool II: Nurses' knowledge about Oxytocic administration questionnaire and Tool III: Nurses' compliance with oxytocic administration observational checklist. Results: The main study findings showed that only 13% of the subjects had good total score of knowledge , while the majority of them 87% had fair and weak of total score (54% &33%) respectively. Regardless of total score of knowledge (good, fair or weak) all nurses had poor practice. There were also a significant positive relationship between nurses’ knowledge about oxytocic administration and their socio-demographic characteristics (position, the original residence and type of the family) and their nature of work (specifically the number of women assigned to each nurse per shift). Conclusion: all study subjects had weak knowledge and poor practices related to oxytocic administration. Recommendations: It is recommended that midwifery nurses should seek continuing education, as well as attending pre-service and in-service training programs on the safe oxytocic administration guidelines should target all maternity nurses periodically and regularly.